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	Provedor de dados BJMBR (2) Autor Liu,X.J. (2) Deng,L.J. (1) Liang,X.M. (1) Tian,K.Y. (1) Wang,G. (1) Wang,L.X. (1) Wang,Q. (1) Xu,J.D. (1) Zeng,J.P. (1) Zhou,Y.B. (1) Mais... Palavra-chave Apoptosis (1) Burn injury (1) Endothelial cells (1) Fibrosis (1) HSC (1) Hyperpermeability (1) Liver cirrhosis (1) Propofol (1) RBP2 (1) Vimentin (1) Α-SMA (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (1) 2013 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Histone demethylase retinoblastoma binding protein 2 regulates the expression of α-smooth muscle actin and vimentin in cirrhotic livers BJMBR Wang,Q.; Wang,L.X.; Zeng,J.P.; Liu,X.J.; Liang,X.M.; Zhou,Y.B.. Liver cirrhosis is one of the most common diseases of Chinese patients. Herein, we report the high expression of a newly identified histone 3 lysine 4 demethylase, retinoblastoma binding protein 2 (RBP2), and its role in liver cirrhosis in humans. The siRNA knockdown of RBP2 expression in hepatic stellate cells (HSCs) reduced levels of α-smooth muscle actin (α-SMA) and vimentin and decreased the proliferation of HSCs; and overexpression of RBP2 increased α-SMA and vimentin levels. Treatment with transforming growth factor β (TGF-β) upregulated the expression of RBP2, α-SMA, and vimentin, and the siRNA knockdown of RBP2 expression attenuated TGF-β-mediated upregulation of α-SMA and vimentin expression and HSC proliferation. Furthermore, RBP2 was highly... Tipo: Info:eu-repo/semantics/article Palavras-chave: RBP2; Liver cirrhosis; Fibrosis; Α-SMA; Vimentin; HSC. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000900739 Propofol inhibits burn injury-induced hyperpermeability through an apoptotic signal pathway in microvascular endothelial cells BJMBR Tian,K.Y.; Liu,X.J.; Xu,J.D.; Deng,L.J.; Wang,G.. Recent studies have revealed that an intrinsic apoptotic signaling cascade is involved in vascular hyperpermeability and endothelial barrier dysfunction. Propofol (2,6-diisopropylphenol) has also been reported to inhibit apoptotic signaling by regulating mitochondrial permeability transition pore (mPTP) opening and caspase-3 activation. Here, we investigated whether propofol could alleviate burn serum-induced endothelial hyperpermeability through the inhibition of the intrinsic apoptotic signaling cascade. Rat lung microvascular endothelial cells (RLMVECs) were pretreated with propofol at various concentrations, followed by stimulation with burn serum, obtained from burn-injury rats. Monolayer permeability was determined by transendothelial electrical... Tipo: Info:eu-repo/semantics/article Palavras-chave: Burn injury; Hyperpermeability; Propofol; Apoptosis; Endothelial cells. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000500401 Registros recuperados: 2 Primeira ... 1 ... Última

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